geneloh

LOH can be caused by deletion of genomic DNA regions containing the normal copy of tumor suppressor genes. This phenomenon is often seen in tumors and in the ...

由 CA Nichols 著作 · 2020 · 被引用 70 次 — Loss of heterozygosity (LOH) may generate cancer-specific vulnerabilities by eliminating genetic redundancy in cancer cells. LOH occurs when a ...

2023年11月15日 — Loss of heterozygosity (LOH) refers to a specific type of genetic mutation during which there is a loss of one normal copy of a gene or a ...

由 GL Ryland 著作 · 2015 · 被引用 158 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

由 X Zhang 著作 · 2021 · 被引用 31 次 — Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of ...

由 GL Ryland 著作 · 2015 · 被引用 158 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

Loss of heterozygosity (LOH) is defined as the loss of one parent's contribution to the cell, can be caused by direct deletion, deletion due to unbalanced ...

5 天前 — LOH (short for “loss of heterozygosity”) refers to a type of mutation that results in the loss of one copy of a segment of DNA (typically ...

Loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal ...